The Role of Metformin in Diabetes Management: Efficacy and New Insights

Abstract

Metformin has long been a cornerstone in the treatment of type 2 diabetes mellitus (T2DM), celebrated for its effectiveness, safety profile, and affordability. Introduced in the 1950s, it remains the first-line pharmacological treatment for T2DM, prescribed to millions globally. Its ability to lower blood glucose levels and improve insulin sensitivity has cemented its status in diabetes care. However, recent studies have unveiled novel insights into its mechanisms of action, benefits beyond glycemic control, and potential limitations, warranting a renewed discussion on its role in modern diabetes management.